منابع مشابه
Model Revision from Temporal Logic Properties in Computational Systems Biology
Systems biologists build models of bio-molecular processes from knowledge acquired both at the gene and protein levels, and at the phenotype level through experiments done in wild-life and mutated organisms. In this chapter, we present qualitative and quantitative logic learning tools, and illustrate how they can be useful to the modeler. We focus on biochemical reaction models written in the S...
متن کاملHow Can PLOS Computational Biology Help the Biological Sciences?
A year has passed since I took over as the Editor-in-Chief of PLOS Computational Biology, making it a good time to reflect on the journal, reassess the needs of our community, and, broadly, the direction of computational biology within the framework of the biological sciences. The rapid growth in computational power, the masses of data that need to be understood, and the advances in the biologi...
متن کاملToward Computational Cumulative Biology by Combining Models of Biological Datasets
A main challenge of data-driven sciences is how to make maximal use of the progressively expanding databases of experimental datasets in order to keep research cumulative. We introduce the idea of a modeling-based dataset retrieval engine designed for relating a researcher's experimental dataset to earlier work in the field. The search is (i) data-driven to enable new findings, going beyond the...
متن کاملIntroduction to Computational Biology Lecture # 26: Biological Networks
Generally, a network can be represented by a graph: a set V of vertices, and a set E of edges which are pairs (u, v) of vertices in V . Thus, we can use networks in order to describe complex biological systems. The vertices may be proteins, genes or metabolites, and in another level complexes or modules. The edges may describe different sorts of relations between the vertices. Lets count some o...
متن کاملAll biology is computational biology
Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our understanding of life, it makes biological concepts rigorous and testable, and it provides a reference map that holds together individual insights. The next modern synthesis in biology will be driv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/462408a